Cedocef
(Cefoperazone & Sulbactam 1g/2g Vials)
INDICATIONS
- Upper and Lower Respiratory Tract Infections
- Urinary Tract Infections
- Intra-Abdominal Infections (Peritonitis, Cholecystitis, Cholangitis)
- Septicemia
- Meningitis
- Skin and Soft Tissue Infections
- Bone and Joint Infections
- Pelvic Inflammatory Disease, Endometritis, Gonorrhea and Other Infections of the female Genital Tract
DOSAGE AND ADMINISTRATION
- Usual adult dose : 2 to 4 g/day (i.e, 1-2 g/day each of Cefoperazone and Sulbactam) given IV or IM in equally divided doses every 12 hours.
- In severe or refractory infections: Daily dosage may be increased to 8g (i.e, 4g/day each of Cefoperazone and Sulbactam) given IV in equally divided doses every 12 hours.
- Recommended maximum daily dosage of Sulbactam is 4g (8g of the combination).
Cefepime, Trimethoprim/Sulfamethoxazole, Nitrofurantoin, Ciprofloxacin, Amikacin and Cefoperazone + Sulbactam susceptibilities for 248 urine isolates of E. coli
| S.No. | Cefepime | Trimethoprim / sulfamethoxazole | Nitrofurantoin | Ciprofloxacin | Amikacin | Cefoperazone + Sulbactam |
|---|---|---|---|---|---|---|
| Sensitive | 57.2% | 12% | 57.2% | 58% | 55.6% | 70% |
Highest rate of susceptibility was found to Cefoperazone + Sulbactam
Cefoperazone - Sulbactam for treatment of Intra-Abdominal infections : Randomized, Open label, Parallel group study conducted at 17 centers in India
Comparator β-lactam/β-lactamase inhibitor combination
| Group | β-lactam/β-lactamase inhibitor combination & Dose |
|---|---|
| A | Cefoperazone-Sulbactam (2-8 g/day) |
| B | Ceftazidime (2-6 g/day)- Amikacin (15 mg/kg/day)-Metronidazole (500 mg TID) |
| Cefoperazone-Sulbactam | Ceftazidime - Amikacin Metronidazole | |
|---|---|---|
| Continued resolution of clinical signs and symptoms at the 30-day follow-up | 91.9% | 81.8% |
| Microbiologic outcomes | 92.9% | 80% |
| Incidence of treatment related adverse events | 6.5% | 16.4% |
CONCLUSION : Empirical Cefoperazone-Sulbactam monotherapy could be a useful adjunct to surgical intervention for Intra-abdominal infections.