Polyced B
Fosfomycin 4gm Inj.
INDICATIONS
- Serious Pseudomonal infections of the Urinary Tract, Meninges and Bloodstream.
- Meningitis caused by H. influenza.
- Urinary Tract infections caused by E.coli.
- Bacteremia caused by Aerobacter and Klebsiella.
DOSAGE AND ADMINISTRATION
I.V.: Dissolve 500,000 U in 300 to 500 mL of 5% dextrose for continuous drip.
Adults and children: 15,000 to 25,000 U/kg body weight/day in individuals with normal kidney function. This amount should be reduced from 15,000 U/kg downward for individual with kidney impairment. Infusions may be given every 12 hours; however, the total daily dose must not exceed 25,000 U/kg/day.
Infants: Infants with normal kidney function may receive up to 40,000 U/kg/day without adverse effects.
IDSA listed superbugs are¹ 1
P. aeruginosa
Acinetobacter spp.
| ANTIBIOTICS | SENSITIVE (%) |
|---|---|
| Polymyxin B | 44 (100) |
| Tigecycline | 27 (61.4) |
| Cefaperazone / Sulbactam | 19 (33.3) |
| Amikacin | 14 (24.5) |
| Ciprofloxacin | 16 (28) |
| Cotrimoxazole | 13 (22.8) |
| Piperacillin / Tazobactam | 12 (21) |
| Imipenem | 14 (24.5) |
| Doripenem | 13 (22.8) |
| Meropenem | 14 (24.5) |
| Cefuroxime | 7 (12.2) |
| Cefotaxime | 7 (12.2) |
| Ceftriaxone | 6 (10.5) |
| Cefepime | 16 (28) |
| Ceftazidime | 16 (28) |
| Aztreonam | 8 (14) |
The antibiotic sensitivity pattern of 44 isolate of Acinetobacter baumannii²
E. coli
K. pneumoniae
Polymyxin B shows highest susceptibility unlike other comparators. 3