Clindaced
Clindamycin 300mg / 600mg Inj.
INDICATIONS
| Serious Infections | Causing Pathogens |
|---|---|
| Lower Respiratory Infections (pneumonia, empyema and lung abscess) | Anaerobes, Streptococcus pneumoniae, other streptococci (except Enterococcus faecalis ) and Staphylococcus aureus |
| Skin and Skin Structure Infections (cellulitis, abscesses and wound infections) | Streptococcus pyogenes Staphylococcus aureus , and Anaerobes |
| Gynaecological Infections (endometritis, pelvic cellulitis, vaginal cuff infections, nongonococcal tubo-ovarian abscess, salpingitis and pelvic inflammatory disease) | Anaerobes Chlamydia trachoma or tis |
| Intra-abdominal Infections (peritonitis and abdominal abscess) | Anaerobes |
| Septicemia | Staphylococcus aureus Streptococci Enterococcus faecalis Anaerobes |
| Bone and Joint Infections (osteomyelitis and septic arthritis) | Staphylococcus aureus Anaerobes and |
| Pneumocystis jiroveci pneumonia in patients with AIDS | - |
ADMINISTRATION AND DOSAGE
Dosage and route of administration should be considered by severity of infection, the patient’s condition and the
- susceptibility of the causative pathogens. Less complicated infections: 1200 - 1800mg / day administered in 3 or 4 equal doses. Daily adult dosage of clindamycin injection (infections of the intra-abdominal area, female pelvis and other
- complicated or serious infections): 2400 - 2700mg / day given in 2,3 or 4 equal doses
NICE* 2019 Guideline for Diabetic Foot Problems: Prevention and Management1
| Pneumonia Severity | Treatment Site |
|---|---|
| Antibiotics for moderate or severe diabetic foot infection in adults aged 18 years and over | |
| Treatment | Antibiotic and Dosage |
| Antibiotics choices if Pseudomonas aeruginosa suspected or confirmed (guided by microbiological results when available); these antibiotics may also be appropriate in other situations based on microbiological results and specialist advice | Piperacillin with Tazobactam
Clindamycin: 150 to 300mg four times a day orally (can be increased to 450mg four times a day) or 600mg to 2.7g daily intravenously in two to four divided doses, increased if necessary in life-threatening infection to 4.8g daily (maximum per dose 1.2g) With Ciprofloxacin (consider safety issues) And/or Gentamicin |
Guideline for treatment of Pelvic Inflammatory Disease (PID)2
Empiric treatment for PID in the inpaƟent seƫng includes:
- Cefotetan or
- CefoxiƟn or
- Clindamycin (900mg IV every 8 hours) plus gentamicin (3 to 5mg / kg IV once daily)