T-ced
(Ticarcillin Disodium & Clavulanate Potassium 3.1 gm Vial)
DOSAGE AND ADMINISTRATION
| Adult | Dose |
|---|---|
| Patients weighing more than 60kg | 3.1g every 4 or 6 hours |
| Patients weighing less than 60kg | 200-300mg/kg/day, given in divided doses every 4 or 6 hours |
| Intermittent IV infusion over 30 min. | |
| Duration of therapy depends upon the severity of infection but is typically 10-14 days; However, in difficult and complicated infections, more prolonged therapy may be required. | |
Achieve the aim with precision
- The combination of Ticarcillin and Clavulanate does increase activity against Beta -lactamase-producing Staphylococci, E. coli, H. influenzae, Klebsiella spp., Proteus spp., Pseudomonas spp., Providencia spp., N. gonorrhoeae, Moraxella catarrhalis, and Bacteroides spp.
- Ticarcillin-Clavulanate exhibits activity against the multidrug-resistant, non-lactose-fermenting S. maltophilia, and the use of this combination in addition to other antimicrobials (e.g., aztreonam or trimethoprim- sulfamethoxazole) leads to synergistic killing'.
- Ticarcillin/Clavulanic acid was found to be the most active combination against A. baumannii and S. maltophilia.
- Ticarcillin/Clavulanic acid was found to be the most effective compared to piperacillin/tazobactam against A. baumannii.
Diagnosis and Management of Complicated Intra-abdominal Infection in Adults: Guidelines by the SIS and IDSA 2010
Agent and Regimen that May Be Used for the Initial Empiric Treatment of Extra-biliary Complicated Intra-abdominal Infection
| Regimen | Community-acquired infection in adults |
|---|---|
| Mild-to-moderate severity: perforated or abscessed appendicitis and other infections of mild-to-moderate severity | |
| Single Agent | Ticarcillin / Clavulanic acid |