INDICATIONS

• Skin and Soft Tissue infections
• Urinary Tract infections
• Lower Respiratory Tract infections
• Joint and Bone infections
• Septicaemia
• Endocarditis
• Peritonitis

DOSAGE AND ADMINISTRATION

• Total daily dose for adults: 3.375 g every 6 hours.
• Should be administered by slow IV infusion over 30 minutes

DURATION OF THERAPY

Adult Dose

Moderate infections:

• Loading dose: 400mg IM/IV injection on the first day
• Maintenance dose: 200mg IM/IV injection daily

Severe infections:

• Loading dose: Three 400mg IV injections, administered 12 hours
• Maintenance dose: 400mg injection IV/IM daily

Duration of Therapy

• Duration of therapy is determined by the type and severity of infection and the clinical response of the patient.
• In Endocarditis and Osteomyelitis, treatment for 3 weeks or longer is recommended

Teicoplanin versus Vancomycin

• Total adverse events, nephrotoxicity and red man syndrome were significantly less frequent with Teicoplanin as compared to Vancomycin .
• VanB phenotype is more common among glycopeptide-resistant Enterococcus faecalis; this exhibit resistance to Vancomycin, but not Teicoplanin .
• Teicoplanin is as effective as Vancomycin, and it has superior tolerability along with advantages such as once daily bolus administration, IM use, and lack of requirement of routine serum monitoring

Teicoplanin versus other antibiotics

Percentage of resistance among Enterococcus and MRSA among various antibiotics

Teicoplanin has shown least resistance against Enterococcus and MRSA